In experiments on monkeys using glycerol monolaurate (GML) managed to block the transmission of monkeyish immunodeficiency virus (SIV), which is similar to HIV. Although the results of studies with other microbicides are disappointing, the authors of this study believe that such ingredients could be used in the future and in humans. 25 years since the beginning of the HIV / AIDS epidemic - the vaccine is still a feasible dream, so studies are needed in other ways to limit the spread of dangerous viruses, the authors believe. According to them their topikalen microbicides could save millions of lives.
The team found that vaginal exposure to SIV rhesus macaque leads to inflammatory response, which not only does not reduce but increases the risk of SIV infection. This is due to the cluster of CD4 + T-lymphocytes, which are the main target of the virus. CD4 cells infected by the virus is distributed locally and throughout the body. GML application of blocking this inflammatory response and thus supresira infection even after repeated viral exposure. As it may sound alogichno, blocking the natural protective mechanisms of the human body actually prevents infection and its rapid spread. GML is a substance occurring in milk. It is widely used in cosmetic and food products such as protivomikroben and anti-inflammatory agent. For GML was found that there has activity against a number of different toxins and microbes, and that blocking MIP-3a and other cytokines and hemokini, promoting immune response.
